What is Akkermansia?

Akkermansia muciniphila is a next-generation gut bacterium linked to metabolic
health and gut barrier integrity. It naturally resides in the gut lining, where
it helps maintain a healthy mucosal layer, supports digestion, and promotes
balanced immune function.†

Emerging research points to its role in supporting weight management and
overall gut health.†

Our patented EB-AMDK19 strain was originally isolated from the gut of a healthy
adult and has been specifically associated with immune support.† It is the
world's first Akkermansia strain to receive individual ingredient recognition
from the Korean Ministry of Food and Drug Safety (MFDS) for respiratory health,
reflecting a review of its clinically demonstrated functionality and safety.
This recognition applies in the Republic of Korea and does not constitute
evaluation or approval by the U.S. Food and Drug Administration.

FLOUREN products contain the heat-treated (postbiotic) form of this strain.

† These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

The Catalyst for Natural Equilibrium

FLOUREN's EB-AMDK19 goes beyond a probiotic — it is a postbiotic, the
heat-treated form of a single characterized strain isolated from a healthy
human gut. Heat treatment is what makes it shelf-stable, and what lets us
tell you exactly what is in the bottle.

This strain reinforces the gut barrier and supports the body's natural
metabolic pathways, helping your system hold its own equilibrium.†

Precision science, working from within.

† These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.

Decoding Vitality

Total transparency through data. This is the precision FLOUREN brings to your
daily routine.

At FLOUREN, we never settle.

Isolated through proprietary research since 2017, the human-derived EB-AMDK19
is more than just an ingredient. This strain brings the most sophisticated
science available to your daily routine, born from a rigorous selection process.

Meet Akkermansia: The Next-Gen Hero for Your Gut and Metabolism

Discover how these key bioactive molecules work from within.


The Barrier Builders (Amuc_1100, Amuc_2109, Amuc_2173, Diacyl-PE, EVs, SCFAs)
Reinforces your gut's natural defenses and promotes cellular renewal to keep
your gut lining strong.†


The Metabolic Support (EVs, SCFAs, P9, 2-oleoyl glycerol)
Naturally supports the body's metabolic functions.†


The Mind & Mood Support (Amuc_1102, EVs, GABA, SCFAs)
Gently encourages serotonin (5-HT) secretion and supports emotional
well-being.†


The Immune Supporter (AmTARS, Amuc_1100, Diacyl-PE, EVs, SCFAs)
Supports a balanced immune response in the gut environment.†


Gut friendly, Smart Settler (Amuc_1409, Diacyl-PE)
Binds to the gut lining for stable, lasting presence.†

Evidence

Published Research

Peer-reviewed literature on Akkermansia muciniphila and the EB-AMDK19 strain. These studies were published independently and are provided for reference. They do not describe the effects of FLOUREN products.

Human clinical trial — EB-AMDK19

Lee, S. H. et al. (2024). Nutrients, 16(23), 4113.

Multicenter, randomized, double-blind, placebo-controlled trial in adults.

View on PubMed

Animal studies

Si, J. et al. (2024). Frontiers in Microbiology, 15, 1386428.

Murine model.

View on PubMed

Choi, Y. et al. (2021). Microorganisms, 9(10), 2039.

Murine model. Compares live and pasteurized forms.

View on PubMed

Yang, M. et al. (2020). Microorganisms, 8(9), 1413.

Murine model. Strain isolation and characterization.

View on PubMed

Hong, M. G. et al. (2024). Archives of Animal Nutrition, 78(3), 254–272.

Canine study of heat-killed EB-AMDK19.

View on PubMed

Cell culture study

Shim, H. et al. (2019). Journal of Korean Medicine for Obesity Research, 19(2), 106.

In vitro, 3T3-L1 adipocytes.

View journal

Press coverage

NutraIngredients — January 2025

Coverage of the EB-AMDK19 clinical trial.

Read article

Microbiome Post

Coverage of EB-AMDK19 research.

Read article

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.